Just recently a trauma nurse at Memorial Hospital, Modesto, CA was discussing with me the trouble with some of the newer anticoagulants.  She was saying that the bleeding was hard to reverse when the patients are on some of the newer anticoagulants.  I was trying to figure out which ones she was talking about and she said that if I had named them, then she would know.  So here’s my possible list of what was on her mind:

If it wasn’t Fondaparinux (above), then you’re probably thinking of Dabigatran/PRADAXA, Rivaroxaban/XARELTO or Apixaban/ELIQUIS. Can’t just push FFP, vitamin K or Factor VII for anticoagulation reversal.  Any one of these on your mind?