Dexmedetomidine (Precedex)
- Sedation without respiratory depression
- Ideal for use in the Intensive Care Unit.
- Can be used for managing extubations.
- No absolute contraindications
- Compared to Versed (Midazolam), Precedex is associated with less delirium, tachycardia, and hypotension, but had more bradycardia
- Agonist of alpha 2 adrenergic receptors in the brain
- FDA reports that infusions greater than 24 hours in duration include ARDS, respiratory failure, and agitation
Skin and Soft Tissue – Surgical Issues
- Various classification systems for necrotizing skin and soft tissue infections help in the study of the disease, doesn’t necessarily help in the care of the patient.
- Dish water exudates and grey necrotic tissue are macroscopic findings of necrotizing soft tissue infection.
- Along with early debridement, very broad spectrum IV antibiotics is the mainstay of necrotizing soft tissue infection.
- Hyperbaric oxygen is not a proven therapy of necrotizing soft tissue infection.
- Switching from castille soap to a once daily 2% chlorhexidine body wash reduces MRSA colonization rates of Surgical ICU patients.
- MRSA (Methicillin Resistant Staphylococcus Aureus) is currently the leading pathogen of surgical site infection
- Chloraprep (contains alcohol) use must be selective – beware of starting a fire on the surgical site.
- After fasciotomies, negative wound therapy could be helpful for getting rid of edema and keeping wound clean and dry.
- Negative pressure wound systems have been associated with complications of death and injuries.
- Measuring compartment pressures, position of the head and trunk relative to the extremities is important when zeroing the transducer
- When performing a Fasciiotomy – one approach anterolateral incision and then posteromedial incision
- Calciphylaxis is associated with high calcium phosphorus product (Ca x P).
- Infected Calciphylaxis lesions must be completely excised which is associated with a high mortality rate.
- Pressure sores is a “never” event.
- Smoking cessation is a mainstay of managing hidradenitis supperativa
- Carbon dioxide laser excision is now being tried to treat moderate infections of hidradenitis supperativa (not severe enough for hospitalization).
- Biopsy of complex skin lesions is important for diagnosis
- Pyoderma Gangrenosum – 50-70% will have systemic disease (like inflammatory bowel disease (UC / Crohn’s Disease).