Pancreas NeoEndocrine/Islet cell Tumors
Sometimes associated with MEN I (multiple endocrine neoplasia)
Somatostatinoma
- tumor of the delta cells of the endocrine pancreas
- triad of: Diabetes Mellitus, Steatorrhea, and Gallstones
- Most are malignant and have metastasized
Glucagonoma
- Necrolytic Migratory Erythema (NME). found in 70%
- Diabetes Mellitus
- Most are malignant and have metastasized
VIPOMA
- Vasoactive Intestinal Polypeptide tumor
- Verner Morrison syndrome
- Causes WDHHA: Watery Diarrhea, Hypokalemia, Hypochlorhydria, Achlorhydria
- Activation of cellular adenylate cyclase and cAMP production
- 50% malignant
Insulinoma
- 10% malignant
- Whipple’s triad of pancreatic insulinoma – Hypoglycemia, symptoms of hypoglycemia, relief of symptoms when glucose is given.
Gastrinoma
- Zollinger-Ellison Syndrome
- Excess gastric acid production
- Can arise in the duodenum or pancreas
- 60% malignant