Dexmedetomidine (Precedex)

• Sedation without respiratory depression
• Ideal for use in the Intensive Care Unit.
• Can be used for managing extubations.
• No absolute contraindications
• Compared to Versed (Midazolam), Precedex is associated with less delirium, tachycardia, and hypotension, but had more bradycardia
• Agonist of alpha 2 adrenergic receptors in the brain
• FDA reports that infusions greater than 24 hours in duration include ARDS, respiratory failure, and agitation