More common in the stomach and small intestine but can be found anywhere along the GI tract.
Begins in cells called th interstitial cells of Cajal (ICC) – considered the pacemakers of the GI tract
GIST may have a genetic component. Neurofibromatosis type 1 is linked to GIST.
Partial resections are usually adequate with GIST treatment with negative margins. Formal gastrectomy is not usually necessary, nor is partial gastrectomy with nodal dissection. Organ sparing approaches are usually appropriate.